BIOMECHANICS

Biomechanics is the application of mechanical principles to living organisms. This includes bioengineering, the research and analysis of the mechanics of living organisms and the application of engineering principles to and from biological systems. This research and analysis can be carried forth on multiple levels, from the molecular, wherein biomaterials such as collagen and elastin are considered, all the way up to the tissue and organ level. Some simple applications of Newtonian mechanics can supply correct approximations on each level, but precise details demand the use of continuum mechanic.

Aristotle wrote the first book on biomechanics, De Motu Animalium, or On the Movement of Animals. He not only saw animals' bodies as mechanical systems, but pursued questions such as the physiological difference between imagining performing an action and actually doing it. Some simple examples of biomechanics research include the investigation of the forces that act on limbs, the aerodynamics of bird and insect flight, the hydrodynamics of swimming in fish, and locomotion in general across all forms of life, from individual cells to whole organisms. The biomechanics of human beings is a core part of kinesiology.

The application of biomechanical principles to plants and plant organs has developed into the sister field of Plant biomechanics. The many strands of plant biomechanics are described in a text book on the subject by Karl Niklas Plant Biomechanics: An Engineering Approach to Plant Form and Function.

Applied mechanics, most notably thermodynamics and continuum mechanics, and mechanical engineering disciplines such as fluid mechanics and solid mechanics, play prominent roles in the study of biomechanics. By applying the laws and concepts of physics, biomechanical mechanisms and structures can be simulated and studied.

Relevant mathematical tools include linear algebra, differential equations, vector and tensor calculus, numerics and computational techniques such as the finite element method.

The study of biomaterials is of crucial importance to biomechanics. For example, the various tissues within the body's organs, such as skin, bone, and arteries each possess unique material properties. The passive mechanical response of a particular tissue can be attributed to characteristics of the various proteins, such as elastin and collagen, living cells, ground substances such as proteoglycans, and the orientations of fibers within the tissue. For example, if human skin were largely composed of a protein other than collagen, many of its mechanical properties, such as its elastic modulus, would be different.

It has been shown that applied loads and deformations can affect the properties of living tissue. There is much research in the field of growth and remodeling as a response to applied loads. For example, the effects of elevated blood pressure on the mechanics of the arterial wall, the behavior of cardiomyocytes within a heart with a cardiac infarct, and bone growth in response to exercise, and the acclimative growth of plants in response to wind movement, have been widely regarded as instances in which living tissue is remodelled as a direct consequence of applied loads.

Chemistry, molecular biology, and cell biology have much to offer in the way of explaining the active and passive properties of living tissues. For example, in muscle contractions, the binding of myosin to actin is based on a biochemical reaction involving calcium ions and ATP.

Muscle contraction

Muscle fiber generates tension through the action of actin and myosin cross-bridge cycling. While under tension, the muscle may lengthen, shorten or remain the same. Though the term 'contraction' implies shortening, when referring to the muscular system it means muscle fibers generating tension with the help of motor neurons (the terms twitch tension, twitch force and fiber contraction are also used).

Locomotion in most animals is possible only through the repeated contraction of many muscles at the correct times. Contraction is controlled by the central nervous system (CNS), which comprises the brain and spinal cord. Voluntary muscle contractions are initiated in the brain, while the spinal cord initiates involuntary reflexes.

biomaterials

The development of biomaterials is not a new area of science, having existed for around half a century. The study of biomaterials is called biomaterial science. It is a provocative field of science, having experienced steady and strong growth over its history, with many companies investing large amounts of money into the development of new products. Biomaterial science encompasses elements of medicine, biology, chemistry, tissue engineering and materials science.

biomolecule

A biomolecule is any organic molecule that is produced by a living organism, including large polymeric molecules such as proteins, polysaccharides, and nucleic acids as well as small molecules such as primary metabolites, secondary metabolites, and natural products.

As organic molecules, biomolecules consist primarily of carbon and hydrogen, nitrogen, and oxygen, and, to a smaller extent, phosphorus and sulfur. Other elements sometimes are incorporated but are much less common.

Proteoglycans

Proteoglycans are glycoproteins that are heavily glycosylated. They have a core protein with one or more covalently attached glycosaminoglycan (GAG) chain(s). The chains are long, linear carbohydrate polymers that are negatively charged under physiological conditions, due to the occurrence of sulfate and uronic acid groups. Proteoglycans occur in connective tissues of humans.

Classical mechanics

Classical mechanics is used for describing the motion of macroscopic objects, from projectiles to parts of machinery, as well as astronomical objects, such as spacecraft, planets, stars, and galaxies. It produces very accurate results within these domains, and is one of the oldest and largest subjects in science, engineering and technology.

Besides this, many related specialties exist, dealing with gases, liquids, and solids, and so on. Classical mechanics is enhanced by special relativity for objects moving with high velocity, approaching the speed of light; general relativity is employed to handle gravitation at a deeper level; and quantum mechanics handles the wave-particle duality of atoms and molecules.

In physics, classical mechanics is one of the two major sub-fields of study in the science of mechanics, which is concerned with the set of physical laws governing and mathematically describing the motions of bodies and aggregates of bodies. The other sub-field is quantum mechanics.

The term classical mechanics was coined in the early 20th century to describe the system of mathematical physics begun by Isaac Newton and many contemporary 17th century workers, building upon the earlier astronomical theories of Johannes Kepler, which in turn were based on the precise observations of Tycho Brahe and the studies of terrestrial projectile motion of Galileo, but before the development of quantum physics and relativity. Therefore, some sources exclude so-called "relativistic physics" from that category. However, a number of modern sources do include Einstein's mechanics, which in their view represents classical mechanics in its most developed and most accurate form. The initial stage in the development of classical mechanics is often referred to as Newtonian mechanics, and is associated with the physical concepts employed by and the mathematical methods invented by Newton himself, in parallel with Leibniz, and others. This is further described in the following sections. More abstract and general methods include Lagrangian mechanics and Hamiltonian mechanics. Much of the content of classical mechanics was created in the 18th and 19th centuries and extends considerably beyond (particularly in its use of analytical mathematics) the work of Newton

Mechanics

Mechanics is the branch of physics concerned with the behaviour of physical bodies when subjected to forces or displacements, and the subsequent effect of the bodies on their environment. The discipline has its roots in several ancient civilizations (see History of classical mechanics and Timeline of classical mechanics). During the early modern period, scientists such as Galileo, Kepler, and especially Newton, laid the foundation for what is now known as classical mechanics.