Sunday, May 3, 2009

BIOMECHANICS

Biomechanics is the application of mechanical principles to living organisms. This includes bioengineering, the research and analysis of the mechanics of living organisms and the application of engineering principles to and from biological systems. This research and analysis can be carried forth on multiple levels, from the molecular, wherein biomaterials such as collagen and elastin are considered, all the way up to the tissue and organ level. Some simple applications of Newtonian mechanics can supply correct approximations on each level, but precise details demand the use of continuum mechanic.

Aristotle wrote the first book on biomechanics, De Motu Animalium, or On the Movement of Animals. He not only saw animals' bodies as mechanical systems, but pursued questions such as the physiological difference between imagining performing an action and actually doing it. Some simple examples of biomechanics research include the investigation of the forces that act on limbs, the aerodynamics of bird and insect flight, the hydrodynamics of swimming in fish, and locomotion in general across all forms of life, from individual cells to whole organisms. The biomechanics of human beings is a core part of kinesiology.

The application of biomechanical principles to plants and plant organs has developed into the sister field of Plant biomechanics. The many strands of plant biomechanics are described in a text book on the subject by Karl Niklas Plant Biomechanics: An Engineering Approach to Plant Form and Function.

Applied mechanics, most notably thermodynamics and continuum mechanics, and mechanical engineering disciplines such as fluid mechanics and solid mechanics, play prominent roles in the study of biomechanics. By applying the laws and concepts of physics, biomechanical mechanisms and structures can be simulated and studied.

Relevant mathematical tools include linear algebra, differential equations, vector and tensor calculus, numerics and computational techniques such as the finite element method.

The study of biomaterials is of crucial importance to biomechanics. For example, the various tissues within the body's organs, such as skin, bone, and arteries each possess unique material properties. The passive mechanical response of a particular tissue can be attributed to characteristics of the various proteins, such as elastin and collagen, living cells, ground substances such as proteoglycans, and the orientations of fibers within the tissue. For example, if human skin were largely composed of a protein other than collagen, many of its mechanical properties, such as its elastic modulus, would be different.

It has been shown that applied loads and deformations can affect the properties of living tissue. There is much research in the field of growth and remodeling as a response to applied loads. For example, the effects of elevated blood pressure on the mechanics of the arterial wall, the behavior of cardiomyocytes within a heart with a cardiac infarct, and bone growth in response to exercise, and the acclimative growth of plants in response to wind movement, have been widely regarded as instances in which living tissue is remodelled as a direct consequence of applied loads.

Chemistry, molecular biology, and cell biology have much to offer in the way of explaining the active and passive properties of living tissues. For example, in muscle contractions, the binding of myosin to actin is based on a biochemical reaction involving calcium ions and ATP.

Muscle contraction

Muscle fiber generates tension through the action of actin and myosin cross-bridge cycling. While under tension, the muscle may lengthen, shorten or remain the same. Though the term 'contraction' implies shortening, when referring to the muscular system it means muscle fibers generating tension with the help of motor neurons (the terms twitch tension, twitch force and fiber contraction are also used).

Locomotion in most animals is possible only through the repeated contraction of many muscles at the correct times. Contraction is controlled by the central nervous system (CNS), which comprises the brain and spinal cord. Voluntary muscle contractions are initiated in the brain, while the spinal cord initiates involuntary reflexes.

biomaterials

The development of biomaterials is not a new area of science, having existed for around half a century. The study of biomaterials is called biomaterial science. It is a provocative field of science, having experienced steady and strong growth over its history, with many companies investing large amounts of money into the development of new products. Biomaterial science encompasses elements of medicine, biology, chemistry, tissue engineering and materials science.

Saturday, May 2, 2009

biomolecule

A biomolecule is any organic molecule that is produced by a living organism, including large polymeric molecules such as proteins, polysaccharides, and nucleic acids as well as small molecules such as primary metabolites, secondary metabolites, and natural products.

As organic molecules, biomolecules consist primarily of carbon and hydrogen, nitrogen, and oxygen, and, to a smaller extent, phosphorus and sulfur. Other elements sometimes are incorporated but are much less common.

Proteoglycans

Proteoglycans are glycoproteins that are heavily glycosylated. They have a core protein with one or more covalently attached glycosaminoglycan (GAG) chain(s). The chains are long, linear carbohydrate polymers that are negatively charged under physiological conditions, due to the occurrence of sulfate and uronic acid groups. Proteoglycans occur in connective tissues of humans.

Classical mechanics

Classical mechanics is used for describing the motion of macroscopic objects, from projectiles to parts of machinery, as well as astronomical objects, such as spacecraft, planets, stars, and galaxies. It produces very accurate results within these domains, and is one of the oldest and largest subjects in science, engineering and technology.

Besides this, many related specialties exist, dealing with gases, liquids, and solids, and so on. Classical mechanics is enhanced by special relativity for objects moving with high velocity, approaching the speed of light; general relativity is employed to handle gravitation at a deeper level; and quantum mechanics handles the wave-particle duality of atoms and molecules.

In physics, classical mechanics is one of the two major sub-fields of study in the science of mechanics, which is concerned with the set of physical laws governing and mathematically describing the motions of bodies and aggregates of bodies. The other sub-field is quantum mechanics.

The term classical mechanics was coined in the early 20th century to describe the system of mathematical physics begun by Isaac Newton and many contemporary 17th century workers, building upon the earlier astronomical theories of Johannes Kepler, which in turn were based on the precise observations of Tycho Brahe and the studies of terrestrial projectile motion of Galileo, but before the development of quantum physics and relativity. Therefore, some sources exclude so-called "relativistic physics" from that category. However, a number of modern sources do include Einstein's mechanics, which in their view represents classical mechanics in its most developed and most accurate form. The initial stage in the development of classical mechanics is often referred to as Newtonian mechanics, and is associated with the physical concepts employed by and the mathematical methods invented by Newton himself, in parallel with Leibniz, and others. This is further described in the following sections. More abstract and general methods include Lagrangian mechanics and Hamiltonian mechanics. Much of the content of classical mechanics was created in the 18th and 19th centuries and extends considerably beyond (particularly in its use of analytical mathematics) the work of Newton

Mechanics

Mechanics is the branch of physics concerned with the behaviour of physical bodies when subjected to forces or displacements, and the subsequent effect of the bodies on their environment. The discipline has its roots in several ancient civilizations (see History of classical mechanics and Timeline of classical mechanics). During the early modern period, scientists such as Galileo, Kepler, and especially Newton, laid the foundation for what is now known as classical mechanics.

kinetic energy

kinetic energy of an object is the extra energy which it possesses due to its motion. It is defined as the work needed to accelerate a body of a given mass from rest to its current velocity. Having gained this energy during its acceleration, the body maintains this kinetic energy unless its speed changes. Negative work of the same magnitude would be required to return the body to a state of rest from that velocity.

Kinetic energy for single objects is completely frame-dependent (relative). For example, a bullet racing by a non-moving observer has kinetic energy in the reference frame of this observer, but the same bullet has zero kinetic energy in the reference frame which moves with the bullet. The kinetic energy of systems of objects, however, may sometimes not be completely removable by simple choice of reference frame. When this is the case, a residual minimum kinetic energy remains in the system as seen by all observers, and this kinetic energy (if present) contributes to the system's invariant mass, which is seen as the same value in all reference frames, and by all observers.

conservation of energy

The law of conservation of energy states that the total amount of energy in an isolated system remains constant. A consequence of this law is that energy cannot be created or destroyed. The only thing that can happen with energy in an isolated system is that it can change form, that is to say for instance kinetic energy can become thermal energy. Because energy is associated with mass in the Einstein's theory of relativity, the conservation of energy also implies the conservation of mass in isolated systems (that is, the mass of a system cannot change, so long as energy is not permitted to enter or leave the system).

Another consequence of this law is that perpetual motion machines can only work perpetually if they deliver no energy to their surroundings. If such machines produce more energy than is put into them, they must lose mass and thus eventually disappear over perpetual time, and are therefore impossible.

organism

In biology, an organism is any living thing (such as animal, plant, fungus, or micro-organism). In at least some form, all organisms are capable of response to stimuli, reproduction, growth and development, and maintenance of homeostasis as a stable whole. An organism may either be unicellular (single-celled) or be composed of, as in humans, many billions of cells grouped into specialized tissues and organs. The term multicellular (many-celled) describes any organism made up of more than one cell.

The terms "organism" (Greek ὀργανισμός - organismos, from Ancient Greek ὄργανον - organon "organ, instrument, tool") first appeared in the English language in 1701 and took on its current definition by 1834 (Oxford English Dictionary).

Organisms may be divided into the prokaryotic and eukaryotic groups. The prokaryotes represent two separate domains, the Bacteria and ArchaeaAll fungi, animals and plants are eukaryotes. The word "organism" may broadly be defined as an assembly of molecules that function as a more or less stable whole and has the properties of life. However, many sources propose definitions that exclude viruses and theoretically-possible man-made non-organic life forms Viruses are dependent on the biochemical machinery of a host cell for reproduction.

Chambers Online Reference provides a broad definition: "any living structure, such as a plant, animal, fungus or bacterium, capable of growth and reproduction".

In multicellular life the word "organism" usually describes the whole hierarchical assemblage of systems (for example circulatory, digestive, or reproductive) themselves collections of organs; these are, in turn, collections of tissues, which are themselves made of cells. In some plants and the nematode Caenorhabditis elegans, individual cells are totipotent.

Vector calculus

Vector calculus (or vector analysis) is a branch of mathematics concerned with differentiation and integration of vector fields. The term "vector calculus" is sometimes used as a synonym for the broader subject of multivariable calculus, which includes vector calculus as well as partial differentiation and multiple integration. Vector calculus plays an important role in differential geometry and in the study of partial differential equations. It is used extensively in physics and engineering, especially in the description of electromagnetic, gravitational fields and fluid flow

Vector calculus was developed from quaternion analysis by J. Willard Gibbs and Oliver Heaviside near the end of the 19th century, and most of the notation and terminology was established by Gibbs and Wilson in their 1901 book, Vector Analysis.

Kinesiology,

Kinesiology, also known as human kinetics, is the science of human movement. It focuses on how the body functions and moves. A kinesiological approach applies scientific based medical principles towards the analysis, preservation and enhancement of human movement in all settings and populations. Kinesiologists work in research, the fitness industry, clinically, and in industrial environments. Studies on human motion may be supported by computer vision, using stereo camera systems for pose recognition and motion modeling

It is not to be confused with applied kinesiology, a controversial alternative medicine technique.

Solid mechanics

Solid mechanics is the branch of mechanics, physics, and mathematics that concerns the behavior of solid matter under external actions (e.g., external forces, temperature changes, applied displacements, etc.). It is part of a broader study known as continuum mechanics. One of the most common practical applications of Solid Mechanics is the Euler-Bernoulli beam equation. Solid mechanics extensively uses tensors to describe stresses, strains, and the relationship between them.

Fluid mechanics

Fluid mechanics is the study of how fluids move and the forces on them. (Fluids include liquids and gases.) Fluid mechanics can be divided into fluid statics, the study of fluids at rest, and fluid dynamics, the study of fluids in motion. It is a branch of continuum mechanics, a subject which models matter without using the information that it is made out of atoms. Fluid mechanics, especially fluid dynamics, is an active field of research with many unsolved or partly solved problems. Fluid mechanics can be mathematically complex. Sometimes it can best be solved by numerical methods, typically using computers. A modern discipline, called Computational Fluid Dynamics (CFD), is devoted to this approach to solving fluid mechanics problems. Also taking advantage of the highly visual nature of fluid flow is Particle Image Velocimetry, an experimental method for visualizing and analyzing fluid flow. Fluid mechanics is the branch of physics which deals with the properties of fluids, namely liquids and gases, and their interaction with forces.

Muscle fiber

Muscle fiber generates tension through the action of actin and myosin cross-bridge cycling. While under tension, the muscle may lengthen, shorten or remain the same. Though the term 'contraction' implies shortening, when referring to the muscular system it means muscle fibers generating tension with the help of motor neurons (the terms twitch tension, twitch force and fiber contraction are also used).

Locomotion in most animals is possible only through the repeated contraction of many muscles at the correct times. Contraction is controlled by the central nervous system (CNS), which comprises the brain and spinal cord. Voluntary muscle contractions are initiated in the brain, while the spinal cord initiates involuntary reflexes.

brachial artery

brachial artery is the major blood vessel of the upper arm.

It is a continuation of the axillary artery beyond the lower margin of teres major muscle. It continues down the ventral surface of the arm until it reaches the cubital fossa at the elbow. It then divides into the radial and ulnar arteries which run down the forearm. In some individuals, the bifurcation occurs much earlier and the ulnar and radial arteries extend through the upper arm. The pulse of the brachial artery is palpable on the anterior aspect of the elbow and, with the use of a stethoscope and sphygmomanometer (blood pressure cuff) often used to measure the blood pressure. The Brachial artery is closely related to the medial nerve; in proximal regions, the median nerve is immediately lateral to the brachial artery. In more distal regions, the median nerve crosses the medial side of the brachial artery and lies anterior to the elbow joint.

Blood pressure

Blood pressure (BP) is the pressure (force per unit area) exerted by circulating blood on the walls of blood vessels, and constitutes one of the principal vital signs. The pressure of the circulating blood decreases as it moves away from the heart through arteries and capillaries, and toward the heart through veins. When unqualified, the term blood pressure usually refers to brachial arterial pressure: that is, in the major blood vessel of the upper left or right arm that takes blood away from the heart. Blood pressure may, however, sometimes be measured at other sites in the body, for instance at the ankle. The ratio of the blood pressure measured in the main artery at the ankle to the brachial blood pressure gives the Ankle Brachial Pressure Index (ABPI).

Continuum mechanics

It is often appropriate to model living tissues as continuous media. For example, at the tissue level, the arterial wall can be modeled as a continuum. This assumption breaks down when the length scales of interest approach the order of the micro structural details of the material. The basic postulates of continuum mechanics are conservation of linear and angular momentum, conservation of mass, conservation of energy, and the entropy inequality. Solids are usually modeled using "reference" or "Lagrangian" coordinates, whereas fluids are often modeled using "spatial" or "Eulerian" coordinates. Using these postulates and some assumptions regarding the particular problem at hand, a set of equilibrium equations can be established. The kinematics and constitutive relations are also needed to model a continuum.

Second and fourth order tensors are crucial in representing many quantities in electromechanical. In practice, however, the full tensor form of a fourth-order constitutive matrix is rarely used. Instead, simplifications such as isotropy, transverse isotropy, and incompressibility reduce the number of independent components. Commonly-used second-order tensors include the Cauchy stress tensor, the second Piola-Kirchhoff stress tensor, the deformation gradient tensor, and the Green strain tensor. A reader of the mechanic's literature would be well-advised to note precisely the definitions of the various tensors which are being used in a particular work.

Pathology

Pathology (from Greek πάθος, pathos, "fate, harm"; and -λογία, -logia) is the study and diagnosis of disease through examination of organs, tissues, bodily fluids and whole bodies (Autopsy). The term also encompasses the related scientific study of disease processes, called General pathology.

Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Ketone bodies

Ketone bodies are three water-soluble compounds that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting.

The three ketone bodies are acetone, acetoacetic acid, and beta-hydroxybutyric acid, although beta-hydroxybutyric acid is not technically a ketone but a carboxylic acid.a

Blood


Blood is a specialized bodily fluid that delivers necessary substances to the body's cells — such as nutrients and oxygen — and transports waste products away from those same cells.

In vertebrates, it is composed of blood cells suspended in a liquid called blood plasma. Plasma, which comprises 55% of blood fluid, is mostly water (90% by volume), and contains dissolved proteins, glucose, mineral ions, hormones, carbon dioxide (plasma being the main medium for excretory product transportation), platelets and blood cells themselves. The blood cells present in blood are mainly red blood cells (also called RBCs or erythrocytes) and white blood cells, including leukocytes and platelets. The most abundant cells in vertebrate blood are red blood cells. These contain hemoglobin, an iron-containing protein, which facilitates transportation of oxygen by reversibly binding to this respiratory gas and greatly increasing its solubility in blood. In contrast, carbon dioxide is almost entirely transported extracellularly dissolved in plasma as bicarbonate ion.

Vertebrate blood is bright-red when its hemoglobin is oxygenated. Some animals, such as crustaceans and mollusks, use hemocyanin to carry oxygen, instead of hemoglobin. Insects and some molluscs use a fluid called hemolymph instead of blood, the difference being that hemolymph is not contained in a closed circulatory system. In most insects, this "blood" does not contain oxygen-carrying molecules such as hemoglobin because their bodies are small enough for their tracheal system to suffice for supplying oxygen.

BONES


Bones are anisotropic but are approximately transversely isotropic. In other words, bones are stronger along one axis than across that axis, and are approximately the same strength no matter how they are rotated around that axis.

The stress-strain relations of bones can be modeled using Hooke's law, in which they are related by elastic moduli, e.g. Young's modulus, Poisson's ratio or the Lamé parameters. The constitutive matrix, a fourth order tensor, depends on the isotropy of the bone.

Wednesday, March 18, 2009

Cardiac muscle


Cardiac muscle is a type of involuntary striated muscle found in the walls of the heart, specifically the myocardium. Cardiac muscle cells are known as cardiac myocytes (or cardiomyocytes).

Cardiac muscle is one of three major types of muscle, the others being skeletal and smooth muscle. The cells that comprise cardiac muscle are sometimes seen as intermediate between these two other types in terms of appearance, structure, metabolism, excitation-coupling and mechanism of contraction.

Cardiac muscle shares similarities with skeletal muscle with regard to its striated appearance and contraction, with both differing significantly from smooth muscle cells. Coordinated
contraction of cardiac muscle cells in the heart propel blood from the atria and ventricles to the blood vessels of the circulatory system.

Cardiac muscle cells, like all tissues in the body, rely on an ample blood supply to deliver oxygen and nutrients and to remove waste products such as carbon dioxide. The
coronary arteries fulfill this function.

Soft tissues


Soft tissues such as tendon, ligament and cartilage are combinations of matrix proteins and fluid. In each of these tissues the main strength bearing element is collagen, although the amount and type of collagen varies according to the function each tissue must perform.
Elastin is also a major load-bearing constituent within skin, the vasculature, and connective tissues.

The function of tendons is to connect muscle with bone and is subjected to tensile loads. Tendons must be strong to facilitate movement of the body while at the same time remaining compliant to prevent damage to the muscle tissues.

Ligaments connect bone to bone and therefore are stiffer than tendons but are relatively close in their tensile strength. Cartilage, on the other hand, is primarily loaded in compression and acts as a cushion in the joints to distribute loads between bones.

The compressive strength of cartilage is derived mainly from collagen as in tendons and ligaments, however because collagen is comparable to a "wet noodle" it must be supported by cross-links of glycosaminoglycans that also attract water and create a nearly incompressible tissue capable of supporting compressive loads.